| 胡向平.BoPhoz类膦-氨基膦配体在Rh-催化beta-脱氢氨基酸酯的不对称氢化反应中的应用[J].分子催化,2011,(6):485-488 |
| BoPhoz类膦-氨基膦配体在Rh-催化beta-脱氢氨基酸酯的不对称氢化反应中的应用 |
| Rh-Catalyzed Asymmetric Hydrogenation of beat-(Acylamino)acrylates with BoPhoz-type Ligands |
| 投稿时间：2011-11-24 修订日期：2011-11-24 |
| DOI： |
| 中文关键词: 膦-氨基膦配体 铑 氢化 不对称催化 beta-脱氢氨基酸酯 |
| 英文关键词:phosphine-aminophosphine ligands rhodium hydrogenation asymmetric catalysis beta-(acylamino)acrylate |
| 基金项目: |
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| 中文摘要: |
| 将BoPhoz类膦-氨基膦配体应用在Rh-催化beta-脱氢氨基酸酯的不对称氢化反应中，考察了配体结构及反应条件对反应结果的影响，并在优化的条件下研究了各种底物的适用范围，产物的对映选择性达81% ee。 |
| 英文摘要: |
| A series of BoPhoz-type phosphine-aminophosphine ligands were employed in the Rh-catalyzed asymmetric hydrogenation of beta-(acylamino)acrylates. The results indicated that the structure of BoPhoz-type ligands has a significant influence on this hydrogenation, and ligand 3c bearing bis[(3,5-difluoro)phenyl]phosphinoamino moiety and bis[(3,5-dimethyl)phenyl]- phosphino moiety showed the best enantioselectivity. Under the optimal conditions, a variety of beta-(acylamino)acrylates were hydrogenated in enantioselectivities of up to 81% ee. |
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