| 王黎明,陈哲,赵美君,金瑛.硫脲衍生物有机催化蒽酮与硝基烯烃的不对称Michael加成反应[J].分子催化,2018,32(2):187-193 |
| 硫脲衍生物有机催化蒽酮与硝基烯烃的不对称Michael加成反应 |
| Thiourea Derivatives Organocatalyzed Asymmetric Michael Addition Reaction of Anthrone with Nitroalkenes |
| 投稿时间：2018-01-05 修订日期：2018-02-15 |
| DOI： |
| 中文关键词: 硫脲衍生物 有机催化 不对称Michael加成反应 蒽酮 β-硝基烯烃 |
| 英文关键词:thiourea derivatives organocatalysis asymmetric Michael addition anthrone β-nitroalkenes |
| 基金项目:国家自然科学基金（21102055），吉林省教育厅"十三五"科学技术项目（JJKH20170409KJ），吉林省卫生厅创新项目（2017J104）资助，大学生创新创业训练计划项目（201713743010）资助. |
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| 中文摘要: |
| 将硫脲衍生物用于有机催化蒽酮和β-硝基烯烃的不对称Michael加成反应.考察溶剂、温度及催化剂用量等对反应催化性能的影响.结果表明，最佳催化条件为5%（摩尔百分数）催化剂1f，二氯甲烷为溶剂，室温反应.得到了80%~97%的化学产率和最高达99% ee的对映选择性. |
| 英文摘要: |
| The (thio) urea derivatives as organocatalysts were applied in asymmetric Michael addition reaction of anthrone with different nitroalkenes. The effect of solvent, temperature and catalyst loading ammount were investigated. The optimized conditions were confirmed to include CH2Cl2 as the solvent with a 5% loading of catalyst 1f at rt. The desired products were obtained in 80%~97% yield with up to 99%ee. |
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