| 韩小峰,苏力德,李娜.辣根过氧化物酶在有机合成中应用的研究进展[J].分子催化,2025,39(2):166-177 |
| 辣根过氧化物酶在有机合成中应用的研究进展 |
| Research Progress of Horseradish Peroxidase and Its Application in Organic Synthesis |
| 投稿时间：2025-01-20 修订日期：2025-02-26 |
| DOI：10.16084/j.issn1001-3555.2025.02.007 |
| 中文关键词: 辣根过氧化物酶 生物催化 有机合成 催化机制 |
| 英文关键词:horseradish peroxidase biocatalysis organic synthesis catalytic mechanism |
| 基金项目:国家自然科学基金项目(32460230); 内蒙古自治区本级事业单位引进人才科研启动绩效项目(RCQD20003); 内蒙古自治区自然科学基金项目(2024QN02016); 内蒙古民族大学博士科研启动项目(BS608、BS623)[National Natural Science Foundation of China (32460230); Talent Research Project for Public Institution of Inner Mongolia of China (RCQD20003); National Natural Science Foundation of Inner Mongolia of China (2024QN02016); Doctoral Research Project of Inner Mongolia Minzu University (BS608, BS623)]. |
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| 中文摘要: |
| 生物催化氧化反应以其高度的选择性、温和的反应条件以及对环境的友好性, 近年来在有机合成领域逐渐崭露头角, 成为化学合成法的有力替代技术. 辣根过氧化物酶(horseradish peroxidase, HRP)是一种源自植物辣根的氧化酶, 作为一种多功能生物催化剂, 它在烷基过氧化物或过氧化氢的作用下, 能催化有机物的氧传递反应, 表现出高效的催化活性, 为绿色合成工艺提供了一种高效的催化剂选择. 我们旨在对HRP的最新研究进展进行总结分析, 并对HRP的发展趋势进行展望, 以期为HRP在有机合成领域的进一步开发利用提供参考. |
| 英文摘要: |
| Biocatalyzed oxidation reactions have gradually emerged in the field of organic synthesis in recent years due to its exceptional selectivity, gentle reaction conditions, and eco-friendliness, becoming a potent alternative to traditional chemical synthesis methods. Horseradish peroxidase (HRP) is an oxidase derived from plant horseradish. As a multifunctional biocatalyst, it can catalyze the oxygen transfer reaction of organic matter in the presence of alkyl peroxides or hydrogen peroxide, exhibiting high catalytic activity and providing and efficient alternative for green synthesis processes. This review aims to summarize and analyze the latest research progress of HRP as well as to explore potential future directions for its development, offering insights for enhanced utilization of HRP in the field of green synthesis. |
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